Vitamin B12 and methyl-group synthesis
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چکیده
منابع مشابه
Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis.
Serum vitamin B12 levels and unsaturated vitamin B12 binding capacities were measured in 24 patients with multiple sclerosis (MS), 73 patients with other neurological disorders and 21 healthy subjects. There was no decrease in the vitamin B12 levels, however, a significant decrease in the unsaturated vitamin B12 binding capacities was observed in patients with MS when compared with other groups...
متن کاملA solid-phase radioimmunoassay for vitamin B12 in serum, with use of radioiodinated tyrosine methyl ester of vitamin B12.
Although radioassays for vitamin B12 with use of any of several binding proteins have been available for many years, a radioimmunoassay for B12 has not been reported. We describe here such a radioimmunoassay, incorporating, for the first time, a radioiodinated tyrosine methyl ester of B12 as the radioactive tracer. Polypropylene tubes are coated with antiserum raised in a rabbit against B12/bov...
متن کاملAerobic synthesis of vitamin B12: ring contraction and cobalt chelation.
The aerobic biosynthetic pathway for vitamin B12 (cobalamin) biosynthesis is reviewed. Particular attention is focused on the ring contraction process, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed. Previous work had established that this chemically demanding step is facilitated by the action of a mono-oxygenase called CobG, which generates a hydroxy lactone ...
متن کاملVitamin B12–dependent taurine synthesis regulates growth and bone mass
1Systems Biology of Bone Laboratory, 2Sanger Mouse Genetics Project, Department of Mouse and Zebrafish Genetics, 3Department of Pathogen Genetics, and 4Department of Human Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom. 5Instrument Core Facility, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom. 6Laboratory of Molecular Biology, Medical Research Council, Camb...
متن کاملPossible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer.
Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new field of sulfane sulfur/hydrogen sulfide (S°/H₂S), hydrosulfide derivatives of cobalamins, autoxidation of hydrosulfide radical, radical S-adenos...
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ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 1957
ISSN: 0007-1145,1475-2662
DOI: 10.1079/bjn19570049